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HelpTest Code SGSS Synthetic Glucocorticoid Screen, Serum
Ordering Guidance
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 2 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Useful For
Confirming the presence of listed synthetic glucocorticoids (see Interpretation)
Confirming the cause of secondary adrenal insufficiency
This test is not useful for detection of fluticasone propionate.
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Stable Isotope Dilution Analysis
Reporting Name
Synthetic Glucocorticoid Screen, SSpecimen Type
SerumSpecimen Minimum Volume
1.1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Frozen (preferred) | 14 days | |
| Refrigerated | 7 days | ||
| Ambient | 24 hours |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Negative
Cutoff concentrations
Betamethasone: 0.10 mcg/dL
Budesonide: 0.20 mcg/dL
Dexamethasone: 0.10 mcg/dL
Fludrocortisone: 0.10 mcg/dL
Megestrol acetate: 0.10 mcg/dL
Methylprednisolone: 0.10 mcg/dL
Prednisolone: 0.10 mcg/dL
Prednisone: 0.10 mcg/dL
Triamcinolone acetonide: 0.10 mcg/dL
Values for normal patients not taking these synthetic glucocorticoids should be less than the cutoff concentration (detection limit).
Day(s) Performed
Wednesday
Report Available
5 to 10 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80299
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SGSS | Synthetic Glucocorticoid Screen, S | 43141-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 23593 | Betamethasone | 41745-1 |
| 23594 | Budesonide | 41747-7 |
| 23595 | Dexamethasone | 14062-4 |
| 23596 | Fludrocortisone | 41754-3 |
| 23600 | Megestrol Acetate | 41762-6 |
| 23601 | Methylprednisolone | 14186-1 |
| 23602 | Prednisolone | 12727-4 |
| 23603 | Prednisone | 12434-7 |
| 23605 | Triamcinolone Acetonide | 41767-5 |