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HelpTest Code PNTFT Phenytoin, Total and Free, Serum
Specimen Required
Collection Container/Tube: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 2 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial within 2 hours of collection.
Useful For
Monitoring for appropriate therapeutic concentration of both free and total phenytoin: free phenytoin level is the best indicator of adequate therapy in renal failure
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| PNYF | Phenytoin, Free, S | Yes | Yes |
| PNYA | Phenytoin, Total, S | Yes | Yes |
Method Name
PNYF: Membrane Separation/KIMS
PNYA: Kinetic interaction of Microparticles in a Solution (KIMS)
Reporting Name
Phenytoin, Total and Free, SSpecimen Type
Serum RedSpecimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 7 days | |
| Frozen | 14 days | ||
| Ambient | 7 days |
Reject Due To
| Gross hemolysis | Reject |
Reference Values
Phenytoin, Total
Therapeutic: 10.0-20.0 mcg/mL
Critical value: ≥30.0 mcg/mL
Phenytoin, Free
Therapeutic: 1.0-2.0 mcg/mL
Critical value: ≥2.5 mcg/mL
Day(s) Performed
Monday through Sunday
Report Available
Same day/1 dayPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
Phenytoin, total-80185
Phenytoin, free-80186
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PNTFT | Phenytoin, Total and Free, S | 34540-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| PNYF | Phenytoin, Free, S | 3969-3 |
| PNYA | Phenytoin, Total, S | 3968-5 |
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.