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Test Code PIPA Pipecolic Acid, Serum


Necessary Information


Patient's age is required.



Specimen Required


Patient Preparation: Fasting 12 hours or more. (Collect specimens from infants and small children just before next feeding)

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Useful For

Differentiating between disorders of peroxisomal biogenesis (eg, Zellweger syndrome) and disorders with loss of a single peroxisomal function

 

Detecting abnormal elevations of pipecolic acid in serum

Method Name

Gas Chromatography Mass Spectrometry (GC-MS)

Reporting Name

Pipecolic Acid, S

Specimen Type

Serum

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 94 days
  Refrigerated  14 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

<6 months: ≤6.0 nmol/mL

6 months-<1 year: ≤5.9 nmol/mL

1-17 years: ≤4.3 nmol/mL

≥18 years: ≤7.4 nmol/mL

Day(s) Performed

Tuesday

Report Available

3 to 9 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82542

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PIPA Pipecolic Acid, S 32334-5

 

Result ID Test Result Name Result LOINC Value
81326 Pipecolic Acid, S 32334-5
29962 Interpretation 59462-2
29964 Reviewed By 18771-6

Testing Algorithm

For more information see Epilepsy: Unexplained Refractory and/or Familial Testing Algorithm