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Test Code CYCPK Cyclosporine, Peak, Blood


Ordering Guidance


This test is for specimens collected during a peak period. For specimens collected at trough, order CYCSP / Cyclosporine, Blood.



Necessary Information


Date of last dose, time of last dose, and dosage information are required.



Specimen Required


Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL

Collection Instructions:

1. Do not centrifuge.

2. Send whole blood specimen in original tube. Do not aliquot.

Additional Information: No definitive therapeutic or toxic ranges have been established for this peak testing.


Useful For

Monitoring whole blood peak cyclosporine concentration during therapy, particularly in individuals coadministered cytochrome P450 (CYP) 3A4 substrates, inhibitors, or inducers

 

Adjusting dose to optimize immunosuppression while minimizing toxicity

 

Evaluating patient compliance

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Cyclosporine, Peak, B

Specimen Type

Whole Blood EDTA

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood EDTA Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK
Clotted specimen Reject

Reference Values

No definitive therapeutic or toxic ranges have been established.

 

Optimal blood drug levels are influenced by type of transplant, patient response, time posttransplant, coadministration of other drugs, and drug formulation.

 

The following 2-hour postdose cyclosporine ranges are only suggested guidelines:

Kidney transplant: 800-1700 ng/mL

Liver transplant: 600-1000 ng/mL

 

Target steady-state peak concentrations vary depending on the type of transplant, concomitant immunosuppression, clinical/institutional protocols, and time posttransplant. Results should be interpreted in conjunction with this clinical information and any physical signs/symptoms of rejection/toxicity.

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 to 2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80158

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CYCPK Cyclosporine, Peak, B 53834-8

 

Result ID Test Result Name Result LOINC Value
42398 Cyclosporine, Peak, B 53834-8
DATEC Date of last dose 29742-4
TIMEC Time of last dose 29637-6
DOSEC Dose, mg 4207-7

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Renal Diagnostics Test Request (T830)

-Therapeutics Test Request (T831)