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HelpTest Code ARSU Arylsulfatase A, 24 Hour, Urine
Ordering Guidance
The preferred test to rule-out metachromatic leukodystrophy is ARSAW / Arylsulfatase A, Leukocytes.
Shipping Instructions
Specimen must be received at least 1 day prior to assay day for processing.
Necessary Information
24-Hour volume (in milliliters) is required.
Specimen Required
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic, 10-mL tube
Specimen Volume: 6 mL
Collection Instructions:
1. Collect a 24-hour urine specimen.
2. No preservative.
3. Refrigerate specimen during collection.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
Forms
1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available:
-Informed Consent for Genetic Testing (T576)
-Informed Consent for Genetic Testing-Spanish (T826)
2. Biochemical Genetics Patient Information (T602)
3. If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.
Useful For
Detection of arylsulfatase A deficiency using urine specimens
This test is not suitable for carrier detection.
Special Instructions
Method Name
Colorimetric, Enzyme Assay
Reporting Name
Arylsulfatase A, USpecimen Type
UrineSpecimen Minimum Volume
2.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated | 14 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
≥19 nmol/h/mL
Note: Results from this assay may not reflect carrier status because of individual variation of arylsulfatase A enzyme levels. Low normal values may be due to the presence of pseudodeficiency or carrier alleles. Patients with these depressed levels may be phenotypically normal.
Day(s) Performed
Tuesday
Report Available
9 to 16 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
84311
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ARSU | Arylsulfatase A, U | 42726-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8777 | Arylsulfatase A, U | 42726-0 |
| 37423 | Interpretation (ARSU) | 59462-2 |
| 37413 | Reviewed By | 18771-6 |
Testing Algorithm
See Lysosomal Storage Disorders Diagnostic Algorithm, Part 2